Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198852 | 0.80 | ADRA1D (0.57) | HTR2CHTR7SIGMAR1ADRA1DADRA1A | |
| SCHEMBL8200402 | 0.80 | HTR2C (0.48) | HTR2CHTR7SIGMAR1 | |
| SCHEMBL8199643 | 0.78 | CCR5 (0.48) | HTR2CHTR7SIGMAR1 | |
| SCHEMBL8198484 | 0.78 | HTR2C (0.42) | HTR2CHTR7SIGMAR1MEN1TP53 | |
| Hydrochloric Acid SCHEMBL8199293 | 0.78 | HTR2C (0.46) | HTR2CLMNAHTR7SIGMAR1KMT2A | |
| SCHEMBL6502613 | 0.77 | CYP19A1 (0.55) | HTR2CLMNAHTR7SIGMAR1POLB | |
| SCHEMBL8588349 | 0.76 | SIGMAR1 (0.44) | HTR2CSMN1; SMN2SIGMAR1POLBMEN1 | |
| SCHEMBL8589678 | 0.76 | SIGMAR1 (0.44) | HTR2CSMN1; SMN2SIGMAR1POLBMEN1 | |
| SCHEMBL8200419 | 0.76 | SIGMAR1 (0.44) | HTR2CSMN1; SMN2SIGMAR1POLBMEN1 | |
| SCHEMBL8200296 | 0.76 | ADRA1D (0.50) | HTR2CHTR7SIGMAR1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |