Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 2/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18222130 | 0.80 | ALOX5 (0.48) | KDM4ELMNATDP1MAPTL3MBTL1 | |
| SCHEMBL8796463 | 0.69 | CASP7 (0.44) | KDM4EALDH1A1GSK3BLMNAMAPT | |
| SCHEMBL4490831 | 0.69 | LRRK2 (0.51) | KDM4EALDH1A1GSK3BLMNAMAPT | |
| SCHEMBL380110 | 0.65 | ALOX5 (0.61) | KDM4EALDH1A1GSK3BLMNATDP1 | |
| SCHEMBL16306320 | 0.63 | KDM4E (0.53) | KDM4EALDH1A1GSK3BLMNATDP1 | |
| SCHEMBL17452157 | 0.63 | CA1 (0.33) | ALDH1A1KMT2A | |
| SCHEMBL11168286 | 0.62 | ACVR1 (0.41) | GSK3BMAPTL3MBTL1PDGFRAFER | |
| SCHEMBL23175285 | 0.60 | CA12 (0.52) | KDM4EALDH1A1GSK3BLMNATDP1 | |
| SCHEMBL6171749 | 0.60 | CASP3 (0.53) | KDM4EALDH1A1GSK3BLMNATDP1 | |
| SCHEMBL19888558 | 0.60 | KDM4E (0.34) | KDM4EPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489657-A2 | Inhibitors of histone deacetylase | MethylGene Inc. (CA) | 2012-08-22 | — | — | EP | disclosed |
| WO-2009137499-A1 | INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |