Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | HTR2A | P28223 | 10/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 6/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202309 | 0.88 | HTR2C (0.43) | DRD2HTR2AHTR1AHTR2CDRD3 | |
| SCHEMBL8199074 | 0.85 | HTR2C (0.48) | DRD2HTR2COPRM1OPRK1MCHR1 | |
| SCHEMBL8198570 | 0.84 | HTR2C (0.47) | DRD2HTR2AHTR2COPRM1OPRK1 | |
| SCHEMBL8199919 | 0.83 | ADRA2A (0.48) | BCHEACHE | |
| SCHEMBL8588802 | 0.83 | HTR2C (0.48) | DRD2HTR2CDRD3OPRM1OPRK1 | |
| SCHEMBL8202767 | 0.82 | HTR2C (0.44) | DRD2HTR2AHTR1AHTR2COPRM1 | |
| SCHEMBL8191625 | 0.82 | DRD2 (0.44) | DRD2HTR2CDRD3 | |
| SCHEMBL8198781 | 0.81 | HTR2C (0.46) | DRD2HTR2CDRD3MCHR1 | |
| SCHEMBL8200603 | 0.81 | HTR2C (0.49) | DRD2HTR2AHTR2C | |
| SCHEMBL8199804 | 0.81 | HTR2C (0.49) | DRD2HTR2COPRM1OPRK1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |