Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208702 | 0.83 | MTNR1A (0.38) | MLKLCYP19A1TP53MAPTRXFP1 | |
| SCHEMBL8195891 | 0.82 | CYP19A1 (0.36) | MLKLCYP19A1 | |
| SCHEMBL8202811 | 0.81 | CYP19A1 (0.35) | MLKLCYP19A1 | |
| SCHEMBL8203579 | 0.80 | MTNR1A (0.38) | MLKLCYP19A1TP53MAPTRXFP1 | |
| SCHEMBL3279617 | 0.79 | MLKL (0.42) | MLKLKIF11CYP19A1TP53MAPT | |
| SCHEMBL8196011 | 0.78 | CYP19A1 (0.34) | MLKLCYP19A1 | |
| SCHEMBL3281218 | 0.76 | MLKL (0.43) | MLKLKIF11CYP19A1TP53MAPT | |
| SCHEMBL4504554 | 0.74 | MLKL (0.41) | MLKLKIF11CYP19A1TP53MAPT | |
| SCHEMBL4501754 | 0.74 | MLKL (0.41) | MLKLKIF11CYP19A1TP53MAPT | |
| SCHEMBL4501760 | 0.74 | MLKL (0.41) | MLKLKIF11CYP19A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043698-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-17 | — | — | WO | disclosed |