Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | TK1 | P04183 | 2/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186763 | 0.84 | DUT (0.44) | DUTKIF11TK1SLC6A1PLA2G2A | |
| SCHEMBL4186770 | 0.84 | DUT (0.44) | DUTKIF11TK1SLC6A1PLA2G2A | |
| SCHEMBL26439425 | 0.77 | PLA2G2A (0.42) | DUTKIF11TK1SLC6A1PLA2G2A | |
| SCHEMBL4191209 | 0.75 | TK1 (0.46) | DUTKIF11TK1CYP2C19CYP2C9 | |
| SCHEMBL4925573 | 0.75 | TK1 (0.46) | DUTKIF11TK1CYP2C19CYP2C9 | |
| SCHEMBL4926228 | 0.75 | TK1 (0.46) | DUTKIF11TK1CYP2C19CYP2C9 | |
| SCHEMBL13377619 | 0.75 | DUT (0.41) | DUTKIF11TK1SLC6A1PLA2G2A | |
| SCHEMBL15942778 | 0.73 | PLA2G2A (0.44) | KIF11PLA2G2APLA2G10PLA2G1BPLA2G5 | |
| SCHEMBL2491921 | 0.72 | KIF11 (0.63) | DUTKIF11TK1SLC6A1CYP2C19 | |
| SCHEMBL5467590 | 0.72 | SLC22A6 (0.38) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776899-B1 | Intermediates and their use to prepare N,N'-bridged bisindolylmaleimides | LILLY CO ELI (US) | 2000-03-29 | — | — | EP | disclosed |
| US-5721272-A | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| US-5665877-A | Synthesis of bisindolylmaleimides | ELI LILLY AND COMPANY (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0776899-A1 | Intermediates and their use to prepare N,N'-bridged bisindolylmaleimides | ELI LILLY AND COMPANY (US) | 1997-06-04 | — | — | EP | disclosed |
| WO-1997019080-A1 | NOVEL INTERMEDIATES AND THEIR USE TO PREPARE N,N'-BRIDGED BISINDOLYLMALEIMIDES | ELI LILLY AND COMPANY (US) | 1997-05-29 | — | — | WO | disclosed |
| US-5614647-A | Intermediates for the synthesis of bisindolylmaleimides | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| EP-0657411-A1 | Improved synthesis of bisindolylmaleimides | ELI LILLY AND COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |