Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205332 | 0.93 | PIK3CD (0.48) | PIK3CDPIK3CAMTORPIK3CGNAMPT | |
| SCHEMBL11925440 | 0.91 | CA2 (0.42) | PIK3CDPIK3CAMTORNAMPTKDM1A | |
| SCHEMBL8213062 | 0.91 | PIK3CD (0.49) | PIK3CDPIK3CAMTORPIK3CGNAMPT | |
| SCHEMBL8215440 | 0.89 | KMT2A (0.43) | PIK3CAMTORPIK3CGNAMPTKDM1A | |
| SCHEMBL8214334 | 0.87 | KIF11 (0.49) | PIK3CAMTORPIK3CGKDM1ACA2 | |
| SCHEMBL11925958 | 0.87 | CA2 (0.46) | PIK3CAMTORPIK3CGNAMPTKDM1A | |
| SCHEMBL8214526 | 0.86 | PIK3CD (0.61) | PIK3CDPIK3CAMTORPIK3CGGHSR | |
| SCHEMBL8215290 | 0.84 | PIK3CD (0.46) | PIK3CDPIK3CAMTORPIK3CGNAMPT | |
| SCHEMBL8217617 | 0.83 | PIK3CA (0.41) | PIK3CDPIK3CAMTORNAMPTCA2 | |
| SCHEMBL8219760 | 0.82 | PIK3CA (0.51) | PIK3CDPIK3CAMTORPIK3CGNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |