Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205334 | 0.92 | PIK3CA (0.41) | KMT2ACA2CA9PIK3CAMTOR | |
| SCHEMBL8214031 | 0.90 | ALDH1A1 (0.46) | KMT2ACA2CA9CA12CA1 | |
| SCHEMBL8214334 | 0.90 | KIF11 (0.49) | CA2CA9CA12CA1CA4 | |
| SCHEMBL8205299 | 0.89 | PIK3CD (0.48) | KMT2ACA2CA9CA12CA1 | |
| SCHEMBL11925958 | 0.89 | CA2 (0.46) | KMT2ACA2CA9CA12CA1 | |
| SCHEMBL11925440 | 0.88 | CA2 (0.42) | KMT2ACA2CA9CA12CA1 | |
| SCHEMBL8214220 | 0.85 | PIK3CA (0.48) | KMT2APIK3CAMTORPIK3CGMEN1 | |
| SCHEMBL8204669 | 0.85 | KMT2A (0.45) | KMT2APIK3CAMTORPIK3CGMEN1 | |
| SCHEMBL8219083 | 0.83 | NAMPT (0.40) | KMT2ACA2CA9CA12CA1 | |
| SCHEMBL11925811 | 0.82 | KIF11 (0.44) | KMT2APIK3CAMTORPTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |