Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 6/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205299 | 0.93 | PIK3CD (0.48) | PIK3CDPIK3CAMTORPIK3CGNAMPT | |
| SCHEMBL8217617 | 0.91 | PIK3CA (0.41) | PIK3CDPIK3CAMTORNAMPT | |
| SCHEMBL8205334 | 0.89 | PIK3CA (0.41) | PIK3CDPIK3CAMTORPIK3CGNAMPT | |
| SCHEMBL8214019 | 0.88 | ATM (0.45) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL11925811 | 0.87 | KIF11 (0.44) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8213062 | 0.87 | PIK3CD (0.49) | PIK3CDPIK3CAMTORPIK3CGNAMPT | |
| SCHEMBL8214526 | 0.86 | PIK3CD (0.61) | PIK3CDPIK3CAMTORPIK3CGGHSR | |
| SCHEMBL8213348 | 0.85 | CYP3A4 (0.40) | PIK3CDPIK3CA | |
| SCHEMBL8214017 | 0.84 | CYP3A4 (0.43) | — | |
| SCHEMBL8215290 | 0.84 | PIK3CD (0.46) | PIK3CDPIK3CAMTORPIK3CGNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |