Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215440 | 0.92 | KMT2A (0.43) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL11925811 | 0.90 | KIF11 (0.44) | PIK3CAMTORKMT2APIK3CDPTGS2 | |
| SCHEMBL8205332 | 0.89 | PIK3CD (0.48) | PIK3CAMTORPIK3CGPIK3CDNAMPT | |
| SCHEMBL8217617 | 0.88 | PIK3CA (0.41) | PIK3CAMTORPIK3CDPTGS2CA2 | |
| SCHEMBL8213348 | 0.88 | CYP3A4 (0.40) | PIK3CAKMT2APIK3CDCA2CA9 | |
| SCHEMBL8214017 | 0.86 | CYP3A4 (0.43) | KMT2APTGS2CA2CA9 | |
| SCHEMBL8214031 | 0.86 | ALDH1A1 (0.46) | PIK3CAMTORPIK3CGKMT2APIK3CD | |
| SCHEMBL8214019 | 0.85 | ATM (0.45) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8204669 | 0.85 | KMT2A (0.45) | PIK3CAMTORPIK3CGKMT2APIP4K2A | |
| SCHEMBL8214220 | 0.85 | PIK3CA (0.48) | PIK3CAMTORPIK3CGKMT2APIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |