Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533320 | 0.86 | KDM4E (0.46) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL22062297 | 0.83 | PLK4 (0.46) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL22048826 | 0.81 | MAPT (0.46) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL124755 | 0.80 | KDM4E (0.48) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL889790 | 0.79 | PLK4 (0.41) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL3420814 | 0.79 | HTR1A (0.45) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL11745635 | 0.79 | RAB9A (0.59) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL11747833 | 0.79 | RAB9A (0.56) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL31221504 | 0.78 | MAPK1 (0.49) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL532379 | 0.77 | MAPT (0.46) | MAPK1PLK4DAPK3DYRK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359454-B1 | CC-1065 analogs having two CPI subunits | UPJOHN CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0359454-A1 | Novel CC-1065 analogs having two CPI subunits | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |