Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273539 | 0.89 | GAA (0.43) | ALDH1A1KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL8205834 | 0.86 | GAA (0.42) | ALDH1A1KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL8205928 | 0.83 | NAMPT (0.39) | ALDH1A1KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL4642176 | 0.80 | NAMPT (0.37) | KDM4ENAMPTHTR2BMAPK14 | |
| SCHEMBL8205624 | 0.78 | CA2 (0.46) | ALDH1A1SMN1; SMN2GAAKMT2AMAPK1 | |
| SCHEMBL8206086 | 0.77 | GAA (0.43) | ALDH1A1KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL8050114 | 0.77 | KMT2A (0.51) | ALDH1A1KDM4ESMN1; SMN2HTTNPC1 | |
| SCHEMBL8199051 | 0.74 | MRGPRX4 (0.43) | ALDH1A1KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL8204858 | 0.74 | GAA (0.36) | ALDH1A1KDM4ESMN1; SMN2HTTGAA | |
| SCHEMBL8271519 | 0.73 | SLC6A4 (0.37) | ALDH1A1KDM4ESMN1; SMN2HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |