Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 4/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210433 | 0.90 | KMT2A (0.55) | GAALMNAALOX15HSD17B10MAPT | |
| SCHEMBL8212496 | 0.88 | GAA (0.56) | GAALMNAHPGDPDE5AAPEX1 | |
| SCHEMBL8207980 | 0.87 | GAA (0.55) | GAALMNAHPGDPDE5AAPEX1 | |
| SCHEMBL7881483 | 0.84 | TSHR (0.47) | GAALMNAALOX15HSD17B10HPGD | |
| SCHEMBL7428203 | 0.80 | ALDH1A1 (0.53) | GAALMNAHPGDMAPTHTT | |
| SCHEMBL8207730 | 0.80 | ALDH1A1 (0.51) | GAALMNAHPGDMAPTKMT2A | |
| SCHEMBL8206949 | 0.80 | LMNA (0.57) | LMNAHSD17B10HPGDAPEX1KMT2A | |
| SCHEMBL8199034 | 0.78 | GAA (0.50) | GAALMNAHPGDMAPTPDE5A | |
| SCHEMBL8199058 | 0.78 | THRB (0.52) | GAALMNAALOX15HSD17B10MAPT | |
| SCHEMBL8206773 | 0.78 | CYP3A4 (0.53) | GAALMNAALOX15HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |