Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.67 |
| ▸ | LTA4H | P09960 | 6/20 | 0.67 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723651 | 0.86 | TRPM8 (0.78) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL7731853 | 0.85 | TRPM8 (0.77) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL19427650 | 0.84 | KMT2A (0.58) | TRPM8LTA4HPLA2G2APOLBMTNR1A | |
| SCHEMBL4490807 | 0.84 | PPARG (0.71) | TRPM8LTA4HPLA2G2APOLBMEN1 | |
| SCHEMBL6923780 | 0.84 | MTNR1A (0.82) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL19051463 | 0.84 | TRPM8 (0.68) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL8206907 | 0.83 | TRPM8 (0.73) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL30176255 | 0.82 | LTA4H (0.64) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL853597 | 0.82 | LTA4H (0.64) | TRPM8LTA4HPLA2G2ASIRT2POLB | |
| SCHEMBL18222539 | 0.82 | TRPM8 (0.75) | TRPM8LTA4HPLA2G2ASIRT2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |