Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199055 | 0.94 | AGTR2 (0.43) | AGTR2KMT2AJAK2JAK1SLC18A3 | |
| SCHEMBL8206274 | 0.88 | SLC18A3 (0.43) | AGTR2SLC18A3SIGMAR1GRIN2BALDH1A1 | |
| SCHEMBL8209743 | 0.88 | SLC18A3 (0.43) | AGTR2SLC18A3SIGMAR1GRIN2BALDH1A1 | |
| SCHEMBL8205248 | 0.87 | SLC18A3 (0.45) | AGTR2SLC18A3OPRM1SIGMAR1GRIN2B | |
| SCHEMBL8206587 | 0.87 | SLC18A3 (0.47) | AGTR2SLC18A3OPRM1GRIN2BCHRM3 | |
| SCHEMBL8206397 | 0.86 | AGTR2 (0.38) | AGTR2KMT2AJAK2JAK1OPRM1 | |
| SCHEMBL8206641 | 0.85 | SLC6A4 (0.40) | AGTR2JAK2JAK1OPRM1ALDH1A1 | |
| SCHEMBL8207012 | 0.84 | KDM4E (0.47) | AGTR2OPRM1ALDH1A1CHRM2CHRM4 | |
| SCHEMBL8199247 | 0.82 | AGTR2 (0.42) | AGTR2SLC18A3OPRM1SIGMAR1GRIN2B | |
| SCHEMBL8207101 | 0.82 | CHRM2 (0.46) | KMT2AOPRM1SIGMAR1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999205-A1 | AMINOCYCLOALKANE COMPOUNDS | Mitsubishi-Tokyo Pharmaceuticals, Inc. (JP) | 2000-05-10 | — | — | EP | disclosed |