Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204367 | 0.85 | DRD1 (0.55) | LMNAALDH1A1KDM4EALDH3A1DRD2 | |
| SCHEMBL8204046 | 0.82 | ALDH1A1 (0.52) | L3MBTL1LMNAALDH1A1KDM4EALDH3A1 | |
| SCHEMBL8506985 | 0.78 | HRH4 (0.62) | LMNASMN1; SMN2DRD2DRD1MEN1 | |
| SCHEMBL8994839 | 0.75 | DRD2 (0.67) | HTTALDH1A1KDM4EALDH3A1DRD2 | |
| SCHEMBL8203911 | 0.75 | DRD2 (0.75) | LMNAALDH1A1KDM4EALDH3A1DRD2 | |
| SCHEMBL9050765 | 0.75 | ALDH1A1 (0.57) | ALDH1A1KDM4EALDH3A1DRD2DRD1 | |
| SCHEMBL8202569 | 0.72 | DRD1 (0.64) | LMNAALDH1A1KDM4EALDH3A1DRD2 | |
| SCHEMBL8203933 | 0.71 | DRD2 (0.74) | LMNAALDH1A1KDM4ESMN1; SMN2ALDH3A1 | |
| SCHEMBL8204038 | 0.71 | DRD2 (0.69) | LMNAALDH1A1KDM4ESMN1; SMN2ALDH3A1 | |
| SCHEMBL8204496 | 0.70 | DRD2 (0.77) | LMNAHTTALDH1A1SMN1; SMN2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103715-A | COMPOUNDS THAT BIND TO THE DOPAMINE D4 RECEPTOR AND THEIR USE AS ANXIOLYTIC AGENTS, TREATMENT FOR SCHIZOPHRENIA, AND DRUG SCREENING; SIDE EFFECT REDUCTIOON | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-15 | — | — | US | disclosed |
| US-5538965-A | TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA AND ANXIETY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1996-07-23 | — | — | US | disclosed |