Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | APAF1 | O14727 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CASP6 | P55212 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 2/20 | 0.57 |
| ▸ | CASP7 | P55210 | 2/20 | 0.57 |
| ▸ | CASP4 | P49662 | 1/20 | 0.57 |
| ▸ | CASP9 | P55211 | 1/20 | 0.57 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.49 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11616274 | 0.85 | CASP1 (0.60) | KMT2AMEN1APAF1ALDH1A1HPGD | |
| SCHEMBL21176664 | 0.81 | CA12 (0.70) | KMT2AMEN1HPGDCASP6CASP3 | |
| SCHEMBL8566878 | 0.80 | KMT2A (0.71) | KMT2AMEN1APAF1ALDH1A1HPGD | |
| SCHEMBL2586644 | 0.78 | KMT2A (1.00) | KMT2AMEN1APAF1ALDH1A1HPGD | |
| SCHEMBL29609544 | 0.78 | KMT2A (1.00) | KMT2AMEN1APAF1ALDH1A1HPGD | |
| SCHEMBL27377022 | 0.76 | POLB (0.62) | KMT2AMEN1ALDH1A1HPGDMAPT | |
| SCHEMBL27881879 | 0.75 | CASP3 (0.81) | ALDH1A1HPGDMAPTCASP6CASP3 | |
| SCHEMBL9097823 | 0.75 | DRD2 (0.57) | KMT2AMEN1ALDH1A1MAPTCASP6 | |
| SCHEMBL2616865 | 0.74 | TDP2 (0.52) | KMT2AMEN1ALDH1A1MAPTCASP6 | |
| SCHEMBL1997187 | 0.73 | MAPT (0.50) | KMT2AMEN1ALDH1A1MAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0944602-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023593-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1998-06-04 | — | — | WO | disclosed |