Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422687 | 0.92 | LMNA (0.50) | LMNAHPGDROCK2GAAMEN1 | |
| SCHEMBL8245383 | 0.91 | ROCK2 (0.52) | LMNAHPGDROCK2GAAMEN1 | |
| SCHEMBL8200517 | 0.91 | SMN1; SMN2 (0.53) | LMNAHPGDGAAMEN1KMT2A | |
| SCHEMBL8207730 | 0.89 | ALDH1A1 (0.51) | LMNAHPGDROCK2GAAMEN1 | |
| SCHEMBL8199066 | 0.84 | LMNA (0.52) | LMNAHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7888438 | 0.83 | ROCK2 (0.52) | LMNAHPGDROCK2GAAMEN1 | |
| SCHEMBL7892988 | 0.83 | NR1H4 (0.58) | HPGDGAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL8207400 | 0.83 | CNR2 (0.49) | LMNAMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8210714 | 0.83 | KDM4E (0.51) | LMNAHPGDGAAMEN1KMT2A | |
| SCHEMBL7428203 | 0.81 | ALDH1A1 (0.53) | LMNAHPGDROCK2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |