Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metiazinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metiazinic Acid SCHEMBL30190433 | 0.81 | LMNA (0.59) | MAPTTP53KDM4ESLC6A3LMNA | |
| Metiazinic Acid SCHEMBL30697757 | 0.81 | LMNA (0.59) | MAPTTP53KDM4ESLC6A3LMNA | |
| Metiazinic Acid SCHEMBL150554 | 0.81 | LMNA (0.59) | MAPTTP53KDM4ESLC6A3LMNA | |
| Metiazinic Acid SCHEMBL10820947 | 0.81 | LMNA (0.59) | MAPTTP53KDM4ESLC6A3LMNA | |
| SCHEMBL28555924 | 0.78 | NOX1 (0.57) | MAPTSLC6A3LMNAMAOASLC6A2 | |
| Nabumetone SCHEMBL3362072 | 0.76 | RAB9A (0.86) | MAPTTP53KDM4ESLC6A3LMNA | |
| Nabumetone SCHEMBL29373228 | 0.74 | CYP1A2 (1.00) | MAPTTP53KDM4ESLC6A3LMNA | |
| Nabumetone SCHEMBL29570823 | 0.74 | CYP1A2 (1.00) | MAPTTP53KDM4ESLC6A3LMNA | |
| Nabumetone SCHEMBL3853067 | 0.74 | CYP1A2 (1.00) | MAPTTP53KDM4ESLC6A3LMNA | |
| Nabumetone SCHEMBL2256 | 0.74 | CYP1A2 (1.00) | MAPTTP53KDM4ESLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977725-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998032718-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 1998-07-30 | — | — | WO | disclosed |