SCHEMBL8209348

SCHEMBL8209348

O=C(Oc1c(Cl)cccc1Cl)c1ccccc1O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.58
HSD17B10 Q99714 4/20 0.58
ALOX15 P16050 1/20 0.58
ESR1 P03372 5/20 0.56
ESR2 Q92731 5/20 0.56
ALDH1A1 P00352 5/20 0.53
KDM4E B2RXH2 3/20 0.53
TSHR P16473 2/20 0.52
LMNA P02545 1/20 0.52
TDP1 Q9NUW8 2/20 0.47
KMT2A Q03164 4/20 0.45
POLB P06746 1/20 0.45
GAA P10253 1/20 0.45
MEN1 O00255 3/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
HMGB1 P09429 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8205941 0.86 HPGD (0.54) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL12919768 0.84 HPGD (0.59) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL8204774 0.82 HPGD (0.67) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL10785217 0.81 ESR1 (0.64) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL9304475 0.79 HSD17B10 (0.58) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL8206089 0.79 HPGD (0.58) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL27757206 0.78 ESR1 (0.55) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL28634919 0.76 HPGD (0.50) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL9161406 0.76 LMNA (0.50) HPGDHSD17B10ALOX15ESR1ESR2
SCHEMBL6659667 0.75 HPGD (0.73) HPGDHSD17B10ALOX15ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4513052-A LEUCO DYE, FLUORAN DYE AND A PHENOLIC COMPOUND RICOH CO., LTD. (JP) 1985-04-23 US claimed
US-6117562-A A THERMAL IMAGE TRANSFER INK LAYER FORMED ON THE SUPPORT; INK LAYER COMPRISING A COLORING AGENT, A RESIN AND A PLASTICIZER FOR LOWERING THE MELT VISCOSITY OF RESIN RICOH COMPANY, LTD. (JP) 2000-09-12 US disclosed
US-5716477-A CONSISTS OF A SUPPORT AND THERMAL IMAGE TRANSFER INK LAYER FORMED ON SAID SUPPORT CONSISTS OF A COLORING AGENT AND A PLASTICIZER FOR LOWERING MELT VISCOSITY OF THE RESIN, HIGH THERMOSENSITIVITY ON CLOTH, PLASTIC, OR PAPER RECEIVER RICOH COMPANY, LTD. (JP) 1998-02-10 US disclosed
US-4562448-A Heat-sensitive transfer medium RICOH CO., LTD. (JP) 1985-12-31 US disclosed
US-4513052-A LEUCO DYE, FLUORAN DYE AND A PHENOLIC COMPOUND RICOH CO., LTD. (JP) 1985-04-23 US disclosed