Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245383 | 0.93 | ROCK2 (0.52) | LMNASMN1; SMN2TDP1HPGDMAPT | |
| SCHEMBL7890903 | 0.92 | NR1H4 (0.57) | LMNASMN1; SMN2TDP1KMT2A | |
| SCHEMBL8200517 | 0.89 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2TDP1HPGDMAPT | |
| SCHEMBL8206929 | 0.87 | ALDH1A1 (0.56) | LMNASMN1; SMN2TDP1HPGDMAPT | |
| SCHEMBL8206605 | 0.86 | NPC1 (0.48) | LMNASMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL8206330 | 0.85 | MEN1 (0.50) | LMNASMN1; SMN2HPGDMAPTKMT2A | |
| SCHEMBL7888438 | 0.85 | ROCK2 (0.52) | LMNASMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL8209588 | 0.84 | LMNA (0.50) | LMNASMN1; SMN2TDP1HPGDMAPT | |
| SCHEMBL8207730 | 0.83 | ALDH1A1 (0.51) | LMNASMN1; SMN2HPGDMAPTKMT2A | |
| SCHEMBL8212431 | 0.83 | TDP1 (0.54) | LMNASMN1; SMN2TDP1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |