Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490343 | 0.86 | ALDH1A1 (0.46) | PLA2G4BPLA2G2APLA2G4ANPC1MAPT | |
| SCHEMBL7878279 | 0.73 | MAPT (0.59) | NPC1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL458027 | 0.71 | ALOX15 (0.67) | PLA2G4BMAPTGAAALDH1A1CYP2C19 | |
| SCHEMBL3373804 | 0.70 | HPGD (0.47) | PLA2G4BNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6247942 | 0.70 | PLA2G4B (0.57) | PLA2G4BPLA2G4AALOX15 | |
| SCHEMBL9770243 | 0.70 | LTA4H (0.53) | MAPTRAB9ALMNAALDH1A1 | |
| SCHEMBL11356807 | 0.70 | ALDH1A1 (0.54) | NPC1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL11457622 | 0.69 | SMN1; SMN2 (0.52) | NPC1MAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL464497 | 0.69 | ALOX15 (0.63) | PLA2G4BNPC1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL1743419 | 0.69 | PLA2G4B (0.57) | PLA2G4BPLA2G4AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6020343-A | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors | MERCK FROSST CANADA, INC. (CA) | 2000-02-01 | — | — | US | disclosed |