Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218768 | 0.86 | ALDH1A1 (0.51) | RAB9ANPC1PIK3CDPIK3CAKMT2A | |
| SCHEMBL8214220 | 0.84 | PIK3CA (0.48) | PIK3CDPIK3CAKMT2AMEN1MTOR | |
| SCHEMBL11926097 | 0.83 | RAB9A (0.43) | RAB9APOLBNPC1PIK3CDPIK3CA | |
| SCHEMBL8213175 | 0.82 | PIK3CA (0.51) | RAB9APOLBNPC1PIK3CDPIK3CA | |
| SCHEMBL8206578 | 0.81 | PIK3CD (0.46) | PIK3CDPIK3CAKMT2AMEN1 | |
| SCHEMBL8214526 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8213776 | 0.81 | CA12 (0.48) | PIK3CDPIK3CA | |
| SCHEMBL8090195 | 0.79 | RAB9A (0.47) | RAB9APOLBNPC1PIK3CDPIK3CA | |
| SCHEMBL8216529 | 0.79 | PIK3CD (0.53) | PIK3CDPIK3CAKMT2AMEN1MTOR | |
| SCHEMBL3603215 | 0.79 | PIK3CA (0.75) | PIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |