Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758910 | 0.80 | SLC6A3 (0.48) | KDM4EALDH1A1ATMHSD17B10LMNA | |
| SCHEMBL27757223 | 0.80 | ALDH1A1 (0.41) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL8205734 | 0.80 | MAPT (0.43) | GAAKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL20773375 | 0.77 | CYP46A1 (0.58) | ALDH1A1NPC1RAB9ASMN1; SMN2TUBB4A | |
| SCHEMBL29228521 | 0.76 | NNMT (0.41) | GAAKDM4EALDH1A1GLARAB9A | |
| SCHEMBL30280895 | 0.74 | CISD2 (0.40) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL7907897 | 0.74 | MAPK14 (0.45) | ABL1CHEK2SMPD3 | |
| SCHEMBL29228590 | 0.74 | KMT2A (0.50) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL11903297 | 0.73 | ENPP3 (0.42) | ALDH1A1CASP1HSD17B10 | |
| SCHEMBL30960678 | 0.73 | HCRTR2 (0.41) | GAAKDM4EALDH1A1GLARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |