SCHEMBL8214522

SCHEMBL8214522

C=COC(=O)NCCO[Si](C)(C)C(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20336492 0.83 HRH4 (0.34)
SCHEMBL15166635 0.81 ZDHHC20 (0.42) BACE1
SCHEMBL1143295 0.79 TDP1 (0.49) NPSR1
Acetonitrile SCHEMBL9547113 0.77 HRH4 (0.32)
SCHEMBL28516262 0.76 MAPK1 (0.40)
SCHEMBL15941254 0.76 BACE1 (0.32) BACE1
SCHEMBL15863147 0.75 POLB (0.37) BACE1
SCHEMBL27999363 0.74 HPGD (0.38)
SCHEMBL234411 0.74 DUT (0.32)
SCHEMBL21577394 0.74 SMN1; SMN2 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0396364-A2 Novel vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1990-11-07 EP claimed
US-6166236-A Vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 2000-12-26 US disclosed
EP-0396364-B1 Copolymers of vinyl carbonate and vinyl carbamate as contact lens material BAUSCH & LOMB (US) 1997-06-11 EP disclosed
US-5610252-A Vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1997-03-11 US disclosed
US-5070215-A Gas permeable contact lenses BAUSCH & LOMB INCORPORATED (US) 1991-12-03 US disclosed
EP-0396364-A2 Novel vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1990-11-07 EP disclosed