Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12734079 | 0.69 | IRAK4 (0.53) | PIK3CAPTGS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8215737 | 0.69 | PTGS2 (0.40) | PIK3CAPIK3R1PTGS2PRKDCALDH1A1 | |
| SCHEMBL18619678 | 0.69 | LMNA (0.55) | — | |
| SCHEMBL16283544 | 0.68 | PDE10A (0.49) | PIK3CAPIK3R1 | |
| SCHEMBL10092229 | 0.68 | PIK3CA (0.49) | PIK3CAPIK3R1PIK3CD | |
| SCHEMBL25877128 | 0.68 | PIK3CA (0.48) | PIK3CAPIK3R1PTGS2HTTKDM4E | |
| SCHEMBL24766030 | 0.67 | KMT2A (0.47) | PIK3CAALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL1069005 | 0.67 | CNR2 (0.55) | PIK3CAALDH1A1HTTKDM4EHSD17B10 | |
| SCHEMBL18412787 | 0.67 | ALDH1A1 (0.49) | PIK3CAALDH1A1HTTKDM4EHSD17B10 | |
| SCHEMBL8812476 | 0.66 | SMN1; SMN2 (0.35) | ALDH1A1POLBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |