Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228680 | 0.91 | MMP13 (0.45) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL10162874 | 0.90 | MMP13 (0.38) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL8226242 | 0.89 | MAPK1 (0.41) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL8227479 | 0.88 | MEN1 (0.44) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL10162873 | 0.88 | TP53 (0.44) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL8226284 | 0.87 | MMP13 (0.47) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL10162840 | 0.87 | L3MBTL1 (0.48) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL8225360 | 0.87 | LMNA (0.41) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL8225302 | 0.86 | HPGD (0.40) | ADAMTS4MMP3MMP8MMP12MMP13 | |
| SCHEMBL8225958 | 0.86 | TP53 (0.44) | ADAMTS4MMP3MMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |