Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10162891 | 0.92 | MMP13 (0.40) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL8219948 | 0.91 | ADAMTS4 (0.43) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL8227479 | 0.91 | MEN1 (0.44) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL8228615 | 0.89 | MMP13 (0.50) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162873 | 0.89 | TP53 (0.44) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162840 | 0.89 | L3MBTL1 (0.48) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162874 | 0.88 | MMP13 (0.38) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162842 | 0.88 | MMP13 (0.41) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162888 | 0.87 | MMP13 (0.39) | MMP13MMP8ADAMTS4MMP3MMP12 | |
| SCHEMBL10162862 | 0.87 | TP53 (0.40) | MMP13MMP8ADAMTS4MMP3MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |