Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228682 | 0.92 | MMP13 (0.47) | PIK3CAPIK3CDPIK3CGMMP13MAPT | |
| SCHEMBL8225360 | 0.91 | LMNA (0.41) | PIK3CAMMP13ADAMTS4MMP3MMP8 | |
| SCHEMBL10162840 | 0.90 | L3MBTL1 (0.48) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10162873 | 0.90 | TP53 (0.44) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL8225294 | 0.89 | ADAMTS4 (0.38) | PIK3CAMMP13ADAMTS4MMP3MMP8 | |
| SCHEMBL8219979 | 0.89 | PIK3CA (0.43) | PIK3CAMMP13ADAMTS4MMP3MMP8 | |
| SCHEMBL8225958 | 0.89 | TP53 (0.44) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL8225302 | 0.89 | HPGD (0.40) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10162891 | 0.89 | MMP13 (0.40) | PIK3CAMMP13ADAMTS4MMP3MMP8 | |
| SCHEMBL8229036 | 0.88 | KMT2A (0.40) | MMP13ADAMTS4MMP3MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |