SCHEMBL8219973

SCHEMBL8219973

CC(C)COc1ccc(CNC(=O)NCc2ccc(OCC(C)C)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.64
MEN1 O00255 3/20 0.64
KMT2A Q03164 3/20 0.64
ALOX12 P18054 2/20 0.64
CTDSP1 Q9GZU7 1/20 0.63
ACACB O00763 4/20 0.55
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
HTR2A P28223 5/20 0.50
ANPEP P15144 1/20 0.50
USP2 O75604 1/20 0.49
ALDH1A1 P00352 1/20 0.49
POLB P06746 1/20 0.49
HPGD P15428 1/20 0.49
ABCB11 O95342 1/20 0.48
CYP1A2 P05177 1/20 0.48
ADRB2 P07550 1/20 0.48
CHRM2 P08172 1/20 0.48
CHRM1 P11229 1/20 0.48
DRD1 P21728 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20404372 0.89 ACACB (0.64) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL18398515 0.89 MAPT (0.67) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL3032550 0.87 MAPT (0.61) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL20404371 0.87 MAPT (0.61) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL20409449 0.87 MAPT (0.61) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL18412176 0.87 MAPT (0.61) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL18398430 0.82 MAPT (0.56) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL29044511 0.82 MAPT (0.52) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL19845885 0.81 NPC1 (0.56) MAPTMEN1KMT2AALOX12CTDSP1
SCHEMBL19845884 0.81 MAPT (0.58) MAPTMEN1KMT2AALOX12CTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118706967-A Pimulserin tartrate and impurity HPLC detection method 天津天士力圣特制药有限公司 2024-09-27 CN claimed
CN-109613163-A A kind of detection method of tartaric acid Mo Fanselin and its impurity 丽珠集团新北江制药股份有限公司 2019-04-12 CN claimed
CN-118706967-A Pimulserin tartrate and impurity HPLC detection method 天津天士力圣特制药有限公司 2024-09-27 CN disclosed
US-11840515-B2 Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c ACADIA PHARMACEUTICALS INC. (US) 2023-12-12 US disclosed
US-11319288-B2 Method for the preparation of pimavanserin base OLON S.P.A. (IT) 2022-05-03 US disclosed
EP-3725774-B1 PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL AGENT ZAKL FARMACEUTYCZNE POLPHARMA S A (PL) 2022-02-23 EP disclosed
US-20220033356-A1 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL AGENT ZAKLADY FARMACEUTYCZNE POLPHARMA S.A. (PL) 2022-02-03 US disclosed
US-20220024871-A1 METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C ACADIA PHARMACEUTICALS INC. 2022-01-27 US disclosed
EP-3325444-B1 METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C ACADIA PHARM INC (US) 2021-07-07 EP disclosed
US-20210130296-A1 METHOD FOR THE PREPARATION OF PIMAVANSERIN BASE OLON S.P.A. (IT) 2021-05-06 US disclosed
US-10981871-B2 Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form C ACADIA PHARMACEUTICALS INC. (US) 2021-04-20 US disclosed
WO-2017015272-A1 METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C ACADIA PHARMACEUTICALS INC. (US) 2017-01-26 WO disclosed
US-7790899-B2 Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms ACADIA PHARMACEUTICALS, INC. (US) 2010-09-07 US disclosed
US-7790899-B2 Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms ACADIA PHARMACEUTICALS, INC. (US) 2010-09-07 US disclosed
WO-2008144326-A2 SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(L-METHYLPIPERIDIN-4-YL)-N'-(4- (2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS ACADIA PHARMACEUTICALS INC. (US) 2008-11-27 WO disclosed
WO-2007133802-A2 PHARMACEUTICAL FORMULATIONS OF PIMAVANSERIN ACADIA PHARMACEUTICALS INC. (US) 2007-11-22 WO disclosed
US-20070264330-A1 PHARMACEUTICAL FORMULATIONS OF PIMAVANSERIN ACADIA PHARMACEUTICALS, INC. 2007-11-15 US disclosed
US-20070264330-A1 PHARMACEUTICAL FORMULATIONS OF PIMAVANSERIN ACADIA PHARMACEUTICALS, INC. 2007-11-15 US disclosed
US-20070260064-A1 SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS ACADIA PHARMACEUTICALS INC. 2007-11-08 US disclosed
US-20070260064-A1 SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS ACADIA PHARMACEUTICALS INC. 2007-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070264330-A1 PHARMACEUTICAL FORMULATIONS OF PIMAVANSERIN HTR6, HTR5A, HTR7 MAPT 1367/4885MEN1 3198/4885KMT2A 1799/4885
US-11840515-B2 Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c NR3C2, NR2C2, CYP4A22 MAPT 4837/4885MEN1 4247/4885KMT2A 797/4885
US-20070260064-A1 SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS MTAP, CPN1, DNPEP MAPT 1590/4885MEN1 3262/4885KMT2A 913/4885
US-11319288-B2 Method for the preparation of pimavanserin base PAH, PIM1, PIM2 MAPT 2421/4885MEN1 2155/4885KMT2A 163/4885
US-20220024871-A1 METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C NR3C2, NR2C2, CYP4A22 MAPT 4837/4885MEN1 4241/4885KMT2A 795/4885
US-20210130296-A1 METHOD FOR THE PREPARATION OF PIMAVANSERIN BASE PAH, PIM1, PIM2 MAPT 2421/4885MEN1 2155/4885KMT2A 163/4885
US-20220033356-A1 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL AGENT PIM1, PAH, PIM3 MAPT 3362/4885MEN1 3219/4885KMT2A 1317/4885
US-10981871-B2 Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form C NR3C2, CYP4A22, NR2C2 MAPT 4851/4885MEN1 4340/4885KMT2A 983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.