Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12694723 | 0.80 | PGR (0.34) | NPC1RAB9APNMTPGRALDH1A1 | |
| Hydrochloric Acid SCHEMBL822335 | 0.77 | NPC1 (0.34) | NPC1RAB9APGRALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL5688812 | 0.75 | NPC1 (0.34) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL30599774 | 0.75 | NPC1 (0.34) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL16908430 | 0.73 | NPC1 (0.33) | NPC1RAB9APGR | |
| Hydrochloric Acid SCHEMBL978987 | 0.73 | NPC1 (0.36) | NPC1RAB9APNMTPGRHTR2B | |
| Hydrochloric Acid SCHEMBL2779266 | 0.71 | PNMT (0.35) | NPC1RAB9APNMTPGRALDH1A1 | |
| Hydrochloric Acid SCHEMBL820432 | 0.70 | NPC1 (0.36) | NPC1RAB9APNMTALDH1A1HTR7 | |
| Hydrochloric Acid SCHEMBL617844 | 0.70 | NPC1 (0.37) | NPC1RAB9APNMTPGRALDH1A1 | |
| SCHEMBL17644783 | 0.70 | NPC1 (0.40) | NPC1RAB9APNMTPGRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010376-A1 | Multi-Component Catalyst Systems and Polymerization Processes for Forming Broad Composition Distribution Polymers | FINA TECHNOLOGY, INC. (US) | 2012-01-12 | — | — | US | disclosed |