Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 17/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753520 | 0.82 | PARP1 (0.62) | PARP1GRM2 | |
| SCHEMBL13079283 | 0.80 | GRM2 (0.46) | PARP1GRM2 | |
| SCHEMBL3741562 | 0.76 | GAA (0.60) | PARP1GRM2MAPTTP53POLB | |
| SCHEMBL8224004 | 0.75 | MAPK1 (0.47) | PARP1GRM2MAPTTP53POLB | |
| SCHEMBL17571986 | 0.75 | ALDH1A1 (0.43) | PARP1GRM2MAPTTP53POLB | |
| SCHEMBL13078853 | 0.75 | GAA (0.53) | GRM2MAPTTP53POLB | |
| SCHEMBL13774307 | 0.73 | DHPS (0.54) | PARP1GRM2MAPTPOLB | |
| SCHEMBL13266828 | 0.72 | KDM4E (0.52) | PARP1MAPTTP53 | |
| SCHEMBL13078856 | 0.68 | KDM4E (0.52) | GRM2 | |
| SCHEMBL7469699 | 0.68 | ALDH1A1 (0.35) | GRM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292235-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | SECOND GENOME, INC. | 2010-11-18 | — | — | US | disclosed |
| WO-2007109172-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292235-A1 | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | PARP1 1754/4885GRM2 332/4885MAPT 4477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.