Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 11/20 | 0.35 |
| ▸ | PPARA | Q07869 | 7/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196758 | 0.77 | MEN1 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL8195825 | 0.74 | PTGS2 (0.38) | ALDH1A1MEN1KMT2ASMN1; SMN2PTGS1 | |
| SCHEMBL8194817 | 0.74 | PTGS2 (0.40) | CHUKALDH1A1PTGS1PTGS2 | |
| SCHEMBL8187466 | 0.73 | PTGS2 (0.39) | ALDH1A1MEN1KMT2ASMN1; SMN2PTGS1 | |
| SCHEMBL8187488 | 0.73 | GRK6 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL8187508 | 0.73 | MEN1 (0.33) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL8202136 | 0.73 | PTGS2 (0.37) | CHUKALDH1A1NOTUMPTGS1PTGS2 | |
| SCHEMBL8195777 | 0.73 | PTGS2 (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2PTGS1 | |
| SCHEMBL8196136 | 0.71 | PTGS2 (0.38) | SMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL8196086 | 0.69 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | claimed |
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |