Sugi Predict

Sugi Predict / Compounds / SCHEMBL10162862

SCHEMBL10162862

SCHEMBL10162862

CC(=O)c1ccc(CNC(=O)c2cc(C(=O)NCc3ccc4oc(=O)n(C)c4c3)nc3ccnn23)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 3/20 0.40
▸ MAPT P10636 3/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ ADAMTS4 O75173 1/20 0.38
▸ MMP3 P08254 1/20 0.38
▸ MMP8 P22894 1/20 0.38
▸ MMP12 P39900 1/20 0.38
▸ MMP13 P45452 1/20 0.38
▸ POLB P06746 1/20 0.37
▸ KMT2A Q03164 4/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ METTL3 Q86U44 1/20 0.36
▸ METTL14 Q9HCE5 1/20 0.36
▸ PIK3CA P42336 2/20 0.36
▸ LMNA P02545 3/20 0.36
▸ RXFP1 Q9HBX9 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8227479 0.93 MEN1 (0.44) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL10162853 0.93 POLB (0.39) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL8221129 0.92 TP53 (0.39) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL10208197 0.92 TP53 (0.39) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL10162873 0.91 TP53 (0.44) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL10162840 0.91 L3MBTL1 (0.48) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL8225360 0.91 LMNA (0.41) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL10163560 0.91 L3MBTL1 (0.39) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL8225958 0.90 TP53 (0.44) TP53MAPTL3MBTL1ADAMTS4MMP3
SCHEMBL8225302 0.89 HPGD (0.40) TP53MAPTL3MBTL1ADAMTS4MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835441-B2 Heterobicyclic metalloprotease inhibitors AMGEN INC. (US) 2014-09-16 — — US disclosed
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2012-01-19 — — US disclosed
US-7795245-B2 Heterobicyclic metalloprotease inhibitors Atlantos Pharmaceuticals Holding, Inc. (US) 2010-09-14 — — US disclosed
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-12-17 — — US disclosed
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. 2009-05-28 — — US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors MMP13, TIMP3, MMP3 TP53 3627/4885MAPT 3533/4885L3MBTL1 4566/4885
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS MMP13, TIMP3, MMP3 TP53 3627/4885MAPT 3533/4885L3MBTL1 4566/4885
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 TP53 3627/4885MAPT 3533/4885L3MBTL1 4566/4885
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 TP53 3627/4885MAPT 3533/4885L3MBTL1 4566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.