Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30702779 | 0.74 | CRBN (0.63) | CYP3A4TSHRSMN1; SMN2HSD17B10CRBN | |
| SCHEMBL2198674 | 0.74 | CRBN (0.63) | CYP3A4TSHRSMN1; SMN2HSD17B10CRBN | |
| SCHEMBL3032630 | 0.73 | MAP3K5 (0.38) | TDO2CYP1A2CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL37681 | 0.73 | CNR2 (0.43) | CYP1A2CYP3A4TSHRHSD17B10CCNC | |
| SCHEMBL197276 | 0.73 | ALDH1A1 (0.37) | CYP1A2CYP3A4TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL2040290 | 0.72 | MAP4K1 (0.36) | IDH1PIM1 | |
| SCHEMBL853306 | 0.71 | TDO2 (0.49) | TDO2CYP1A2CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL38095 | 0.71 | IDH1 (0.35) | IDH1 | |
| SCHEMBL1461869 | 0.71 | CYP11B2 (0.48) | TDO2CYP1A2CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL182711 | 0.70 | PLD1 (0.53) | CYP1A2CYP3A4TSHRSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | claimed |
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |