Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.35 |
| ▸ | DRD3 | P35462 | 7/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235817 | 0.88 | OPRM1 (0.32) | DRD2OPRM1DRD3DRD4LMNA | |
| SCHEMBL8236145 | 0.85 | DRD2 (0.31) | DRD2OPRM1DRD3DRD4 | |
| SCHEMBL8238023 | 0.79 | NPY2R (0.33) | LMNA | |
| SCHEMBL2104666 | 0.67 | SIRT2 (0.36) | DRD2OPRM1DRD3DRD4LMNA | |
| SCHEMBL14149674 | 0.63 | CYP11B1 (0.31) | — | |
| SCHEMBL13470169 | 0.61 | CYP11B1 (0.33) | — | |
| SCHEMBL13955720 | 0.60 | SMN1; SMN2 (0.40) | OPRM1LMNASMN1; SMN2L3MBTL1BACE1 | |
| SCHEMBL15371487 | 0.59 | GABRA1 (0.44) | DRD2DRD3DRD4LMNASMN1; SMN2 | |
| Hydrogen Peroxide SCHEMBL11529291 | 0.59 | IDO1 (0.52) | OPRM1 | |
| SCHEMBL8305485 | 0.58 | ALDH1A1 (0.39) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |