Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 2/20 | 0.54 |
| ▸ | CTSK | P43235 | 4/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298029 | 1.00 | CTRB1 (0.54) | CTRB1CTSKCTSBPSMB1PSMB5 | |
| SCHEMBL13173061 | 1.00 | CTRB1 (0.54) | CTRB1CTSKCTSBPSMB1PSMB5 | |
| SCHEMBL3337955 | 0.88 | CTSB (0.66) | CTRB1CTSBTACR1 | |
| SCHEMBL5275940 | 0.88 | CTSK (0.59) | CTRB1CTSKCTSBPSMB1PSMB5 | |
| SCHEMBL30825010 | 0.88 | CTSK (0.59) | CTRB1CTSKCTSBPSMB1PSMB5 | |
| SCHEMBL630290 | 0.88 | CTSB (0.66) | CTRB1CTSBTACR1 | |
| SCHEMBL5275932 | 0.88 | CTSK (0.59) | CTRB1CTSKCTSBPSMB1PSMB5 | |
| SCHEMBL3132344 | 0.88 | CTSB (0.66) | CTRB1CTSBTACR1 | |
| SCHEMBL27641158 | 0.87 | CTRB1 (0.52) | CTRB1CTSKCTSBPSMB1PSMB5 | |
| SCHEMBL4425695 | 0.87 | CASP1 (0.55) | CTRB1CTSKCTSBPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |