Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304544 | 0.78 | ALDH1A1 (0.42) | HTTALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL10957254 | 0.77 | ALDH1A1 (0.55) | HTTALDH1A1TSHRMAOAKDM4E | |
| SCHEMBL13304480 | 0.76 | HDAC6 (0.52) | KCNH2HDAC1 | |
| SCHEMBL13304543 | 0.76 | GRIN2C (0.46) | HTTALDH1A1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL10119912 | 0.72 | HTT (0.52) | HTTALDH1A1TSHRMAOAKDM4E | |
| SCHEMBL10119876 | 0.69 | MAOA (0.52) | HTTALDH1A1TSHRMAOAKDM4E | |
| SCHEMBL12154389 | 0.69 | LMNA (0.48) | HTTALDH1A1TSHRMAOAKDM4E | |
| SCHEMBL14074159 | 0.67 | MAPT (0.57) | HTTALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL26508424 | 0.67 | HTR2A (0.68) | HTTALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL28788491 | 0.66 | HTT (0.56) | HTTALDH1A1TSHRKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899325-B1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2011-11-16 | — | — | EP | disclosed |
| WO-2006136553-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | WO | disclosed |