Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10119876 | 0.87 | MAOA (0.52) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL12154389 | 0.86 | LMNA (0.48) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL10957254 | 0.83 | ALDH1A1 (0.55) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL8270960 | 0.76 | SLC6A4 (0.44) | MAOAHDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL27824370 | 0.75 | ALDH1A1 (0.68) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL9883619 | 0.75 | HDAC1 (0.45) | HTTALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL8240955 | 0.74 | SLC6A4 (0.69) | HTTALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL2077801 | 0.73 | CHRNB2 (0.67) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL6878946 | 0.73 | HTT (0.56) | HTTALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL8239496 | 0.72 | HTT (0.46) | HTTALDH1A1TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781639-B1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-25 | — | — | EP | disclosed |