Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362911 | 0.88 | MAPT (0.42) | MAPTALDH1A1CYP3A4ACHETP53 | |
| SCHEMBL1364594 | 0.83 | ALDH1A1 (0.37) | MAPTALDH1A1CYP3A4ACHEPOLB | |
| SCHEMBL8231615 | 0.79 | ACHE (0.38) | ALDH1A1CYP3A4TSHRACHEMEN1 | |
| SCHEMBL14441565 | 0.71 | PTGS2 (0.38) | ALDH1A1TSHRACHEMEN1KMT2A | |
| SCHEMBL12147265 | 0.68 | PSEN1 (0.39) | ALDH1A1ACHEPOLBMEN1KMT2A | |
| SCHEMBL14441566 | 0.68 | PSEN1 (0.39) | ALDH1A1ACHEPOLBMEN1KMT2A | |
| SCHEMBL12147254 | 0.68 | PSEN1 (0.39) | ALDH1A1ACHEPOLBMEN1KMT2A | |
| SCHEMBL1365544 | 0.68 | PSEN1 (0.40) | ALDH1A1CYP3A4ACHEPOLBMEN1 | |
| SCHEMBL12147236 | 0.68 | DRD2 (0.40) | MAPTALDH1A1TP53LMNA | |
| SCHEMBL11399286 | 0.68 | MAPT (0.44) | MAPTALDH1A1CYP3A4TSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084595-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |