Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12306070 | 0.81 | CYP19A1 (0.65) | CYP19A1PDE4DACHE | |
| SCHEMBL1114939 | 0.77 | PDE4D (0.81) | CYP19A1PDE4DACHE | |
| SCHEMBL3314894 | 0.76 | CYP19A1 (1.00) | CYP19A1PDE4D | |
| SCHEMBL6382100 | 0.75 | PDE4D (0.71) | CYP19A1PDE4DACHE | |
| SCHEMBL6378133 | 0.74 | CYP19A1 (0.81) | CYP19A1PDE4DACHE | |
| SCHEMBL6378154 | 0.74 | CYP19A1 (1.00) | CYP19A1PDE4D | |
| SCHEMBL8320335 | 0.74 | ACHE (0.48) | PDE4DACHE | |
| SCHEMBL16558736 | 0.70 | CYP19A1 (0.41) | CYP19A1PDE4DACHE | |
| SCHEMBL16558739 | 0.69 | CYP19A1 (0.41) | CYP19A1PDE4DACHE | |
| SCHEMBL8265237 | 0.68 | ACHE (0.39) | PDE4DACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954676-B1 | PROCESS FOR MAKING DONEPEZIL | SYNTHON BV (NL) | 2012-11-07 | — | — | EP | disclosed |
| US-20070135644-A1 | PROCESS FOR MAKING DONEPEZIL | SYNTHON BV (NL) | 2007-06-14 | — | — | US | disclosed |
| WO-2007057226-A2 | PROCESS FOR MAKING DONEPEZIL | SYNTHON B.V. (NL) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135644-A1 | PROCESS FOR MAKING DONEPEZIL | MAOA, ACHE, CHAT | CYP19A1 664/4885PDE4D 486/4885ACHE 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.