Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.67 |
| ▸ | CTSB | P07858 | 1/20 | 0.67 |
| ▸ | CTSS | P25774 | 1/20 | 0.67 |
| ▸ | CTSK | P43235 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245179 | 0.89 | CTSL (0.57) | CTSLCTSBCTSSCTSKHRH3 | |
| SCHEMBL8245909 | 0.89 | CTSL (0.52) | CTSLCTSBCTSSCTSKHRH3 | |
| SCHEMBL8245186 | 0.87 | CTSL (0.83) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL8270725 | 0.85 | HRH3 (0.47) | CTSLCTSBCTSSCTSKHRH3 | |
| SCHEMBL8241795 | 0.81 | CTSL (0.69) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL5794602 | 0.81 | CTSL (0.47) | CTSLCTSBCTSSCTSKHRH3 | |
| Trifluoroacetic Acid SCHEMBL5793415 | 0.81 | CTSL (0.43) | CTSLCTSBCTSSCTSKHRH3 | |
| SCHEMBL5592822 | 0.80 | CTSS (0.88) | CTSLCTSBCTSSCTSKTBK1 | |
| SCHEMBL8245231 | 0.80 | CTSL (0.46) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL5592896 | 0.80 | CTSS (1.00) | CTSLCTSBCTSSCTSKTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025776-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |