Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.83 |
| ▸ | CTSB | P07858 | 1/20 | 0.83 |
| ▸ | CTSS | P25774 | 1/20 | 0.83 |
| ▸ | CTSK | P43235 | 1/20 | 0.83 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592618 | 0.93 | CTSL (0.87) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL5593246 | 0.93 | CTSL (0.87) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL5593209 | 0.92 | CTSL (0.86) | CTSLCTSBCTSSCTSKALDH1A1 | |
| SCHEMBL5592896 | 0.91 | CTSS (1.00) | CTSLCTSBCTSSCTSK | |
| SCHEMBL8243091 | 0.91 | CTSL (0.69) | CTSLCTSBCTSSCTSKNPC1 | |
| SCHEMBL8241795 | 0.91 | CTSL (0.69) | CTSLCTSBCTSSCTSKNPC1 | |
| SCHEMBL5592822 | 0.89 | CTSS (0.88) | CTSLCTSBCTSSCTSKJAK2 | |
| SCHEMBL8236641 | 0.89 | CTSL (0.66) | CTSLCTSBCTSSCTSKNPC1 | |
| SCHEMBL8243182 | 0.87 | CTSL (0.67) | CTSLCTSBCTSSCTSKMAPT | |
| Trifluoroacetic Acid SCHEMBL5592621 | 0.87 | CTSL (0.78) | CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025776-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |