Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 1.00 |
| ▸ | CTSK | P43235 | 4/20 | 1.00 |
| ▸ | CTSL | P07711 | 3/20 | 1.00 |
| ▸ | CTSB | P07858 | 2/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3319243 | 0.95 | CTSS (0.90) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5592822 | 0.94 | CTSS (0.88) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5593246 | 0.93 | CTSL (0.87) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5592618 | 0.93 | CTSL (0.87) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5593209 | 0.92 | CTSL (0.86) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5593048 | 0.92 | CTSL (0.85) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL8245022 | 0.92 | CTSS (0.85) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL8245186 | 0.91 | CTSL (0.83) | CTSSCTSKCTSLCTSB | |
| SCHEMBL8243023 | 0.91 | CTSS (0.83) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL8236095 | 0.90 | CTSS (0.82) | CTSSCTSKCTSLCTSBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105652-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED | 2010-04-29 | — | — | US | disclosed |
| US-20100105652-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED | 2010-04-29 | — | — | US | disclosed |
| EP-2028182-A1 | Cysteine protease inhibitors | GLAXO GROUP LIMITED (GB) | 2009-02-25 | — | — | EP | disclosed |
| EP-1972630-A1 | Purines as cysteine protease inhibitors | GLAXO GROUP LIMITED (GB) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105652-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | CPN1, SERPINB1, PNP | CTSS 37/4885CTSK 135/4885CTSL 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.