Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.88 |
| ▸ | CTSK | P43235 | 4/20 | 0.88 |
| ▸ | CTSL | P07711 | 3/20 | 0.88 |
| ▸ | CTSB | P07858 | 2/20 | 0.88 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5592848 | 0.95 | CTSL (0.79) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5592896 | 0.94 | CTSS (1.00) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5592618 | 0.92 | CTSL (0.87) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5593246 | 0.92 | CTSL (0.87) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5592558 | 0.91 | CTSL (0.73) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5593209 | 0.91 | CTSL (0.86) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL5592566 | 0.91 | CTSL (0.73) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL8242573 | 0.90 | CTSS (0.72) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL8245186 | 0.89 | CTSL (0.83) | CTSSCTSKCTSLCTSBJAK2 | |
| SCHEMBL8241787 | 0.89 | CTSK (0.69) | CTSSCTSKCTSLCTSBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | claimed |
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |