Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245338 | 1.00 | TSHR (0.54) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL5218978 | 0.82 | HDAC4 (0.68) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL8252545 | 0.82 | CTSK (0.52) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL8252549 | 0.82 | CTSK (0.52) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL6207008 | 0.82 | HDAC4 (0.68) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL4730477 | 0.82 | ITGB3 (0.48) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL28740619 | 0.81 | LMNA (0.58) | TSHRCTSSCTSKHDAC4HDAC1 | |
| Cyclohexylamine SCHEMBL28856746 | 0.81 | CTSS (0.54) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL11249810 | 0.81 | LMNA (0.58) | TSHRCTSSCTSKHDAC4HDAC1 | |
| SCHEMBL7260228 | 0.81 | LMNA (0.58) | TSHRCTSSCTSKHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |