Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113543 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13483255 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL18669389 | 0.98 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28227396 | 0.98 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| Phosphine SCHEMBL27449508 | 0.98 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28254365 | 0.95 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL30074139 | 0.93 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| Ethyl Acetate SCHEMBL28096321 | 0.91 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29411185 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14616914 | 0.90 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612851-B1 | Process for the preparation of the L-arginine salt of perindopril | SERVIER LAB (FR) | 2016-07-06 | — | — | EP | disclosed |
| EP-1989182-B1 | CRYSTALLINE FORM OF THE ARGININE SALT OF PERINDOPRIL, PROCESS FOR PREPARING IT, AND PHARMACEUTICAL COMPOSITIONS COMPRISING IT | SERVIER LAB (FR) | 2016-04-13 | — | — | EP | disclosed |
| US-8754135-B2 | Functionalized non-phenolic amino acids and absorbable polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2014-06-17 | — | — | US | disclosed |
| EP-2612850-B1 | Delta crystalline form of the arginine salt of perindopril, a process for its preparation, and pharmaceutical compositions containing it | SERVIER LAB (FR) | 2013-09-18 | — | — | EP | disclosed |
| US-8519156-B2 | Functionalized non-phenolic amino acids and absorbable polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2013102741-A1 | DELTA-CRYSTALLINE FORM OF PERINDOPRIL ARGININE SALT, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2013-07-11 | — | — | WO | disclosed |
| WO-2013102740-A1 | METHOD FOR THE PREPARATION OF PERINDOPRIL ARGININE SALT | LES LABORATOIRES SERVIER (FR) | 2013-07-11 | — | — | WO | disclosed |
| EP-2612850-A1 | Delta crystalline form of the arginine salt of perindopril, a process for its preparation, and pharmaceutical compositions containing it | Les Laboratoires Servier (FR) | 2013-07-10 | — | — | EP | disclosed |
| EP-2612851-A1 | Process for the preparation of the L-arginine salt of perindopril | Les Laboratoires Servier (FR) | 2013-07-10 | — | — | EP | disclosed |
| US-20130116446-A1 | FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM | BEZWADA BIOMEDICAL, LLC (US) | 2013-05-09 | — | — | US | disclosed |
| US-7323575-B2 | Process for the synthesis of (2S)-indoline-2-carboxylic acid | LES LABORATORIES SERVIER (FR) | 2008-01-29 | — | — | US | disclosed |
| US-7323575-B2 | Process for the synthesis of (2S)-indoline-2-carboxylic acid | LES LABORATORIES SERVIER (FR) | 2008-01-29 | — | — | US | disclosed |
| US-7279583-B2 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | LES LABORATOIRES SERVIER (FR) | 2007-10-09 | — | — | US | disclosed |
| US-20070197821-A1 | Process for the preparation of high purity perindopril | LES LABORATOIRES SERVIER (FR) | 2007-08-23 | — | — | US | disclosed |
| EP-1268424-B1 | METHOD FOR SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | SERVIER LAB (FR) | 2007-08-08 | — | — | EP | disclosed |
| EP-1333026-B1 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | SERVIER LAB (FR) | 2007-06-27 | — | — | EP | disclosed |
| US-20070112204-A1 | Process for the synthesis of (2S)-indoline-2-carboxylic acid | LES LABORATOIRES SERVIER (FR) | 2007-05-17 | — | — | US | disclosed |
| US-20070112204-A1 | Process for the synthesis of (2S)-indoline-2-carboxylic acid | LES LABORATOIRES SERVIER (FR) | 2007-05-17 | — | — | US | disclosed |
| WO-2007017894-A2 | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE | ARCH PHARMALABS LIMITED (IN) | 2007-02-15 | — | — | WO | disclosed |
| EP-1422236-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | SERVIER LAB (FR) | 2007-02-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197821-A1 | Process for the preparation of high purity perindopril | ACE, AGTR1, ACE2 | SMN1; SMN2 2111/4885ALDH1A1 142/4885MEN1 4424/4885 |
| US-20130116446-A1 | FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM | SLC1A5, SLC7A1, BCAT2 | SMN1; SMN2 4296/4885ALDH1A1 1525/4885MEN1 3775/4885 |
| US-20070112204-A1 | Process for the synthesis of (2S)-indoline-2-carboxylic acid | IMPDH2, PDK4, QDPR | SMN1; SMN2 1824/4885ALDH1A1 74/4885MEN1 3917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.