Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 3/20 | 0.63 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | FNTA | P49354 | 4/20 | 0.51 |
| ▸ | FNTB | P49356 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21686707 | 0.84 | GABBR2 (0.59) | GABBR2GABBR1CYP2D6MEN1KMT2A | |
| SCHEMBL391659 | 0.84 | GABBR2 (0.79) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL7995264 | 0.83 | GABBR2 (0.63) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL13524865 | 0.83 | GABBR2 (0.58) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL28014207 | 0.82 | GABBR2 (0.76) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL11321913 | 0.81 | GABBR2 (0.69) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL22193617 | 0.81 | GABBR2 (0.69) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL27844992 | 0.81 | GABBR2 (0.59) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL7666332 | 0.79 | SLC6A4 (0.47) | GABBR2GABBR1CYP2C9LMNACYP2D6 | |
| SCHEMBL9076600 | 0.79 | GABBR2 (0.71) | GABBR2GABBR1CYP2C9LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3599246-A1 | MEANS AND METHODS FOR SYNTHESIZING PRECURSORS OF Y-AMINOBUTYRIC ACID (GABA) ANALOGS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-01-29 | — | — | EP | disclosed |
| US-8143311-B2 | Methods of treating fragile X syndrome and autism | SEASIDE THERAPEUTICS, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100029770-A1 | Methods of treating mental retardation, down's syndrome, fragile X syndrome and autism | SEASIDE THERAPEUTICS, LLC (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029770-A1 | Methods of treating mental retardation, down's syndrome, fragile X syndrome and autism | GABRB1, GABRB3, GABRB2 | GABBR2 4/4885GABBR1 5/4885CYP2C9 4050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.