SCHEMBL8250577

SCHEMBL8250577

O=C(O)c1ccc2cc(C(=O)O)sc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.61
GPR35 Q9HC97 3/20 0.56
HDAC1 Q13547 6/20 0.55
TBXAS1 P24557 1/20 0.47
KDM4E B2RXH2 5/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
NFKB1 P19838 2/20 0.46
NFKB2 Q00653 2/20 0.46
RELA Q04206 2/20 0.46
LMNA P02545 1/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
HSD17B1 P14061 1/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8260519 0.87 CA2 (0.56) BCL2L1GPR35HDAC1TBXAS1KDM4E
SCHEMBL9612781 0.87 CLK1 (0.51) BCL2L1GPR35HDAC1KDM4ESMN1; SMN2
SCHEMBL1886146 0.87 HDAC1 (0.67) BCL2L1GPR35HDAC1KDM4ESMN1; SMN2
SCHEMBL4082326 0.85 BCL2L1 (0.61) BCL2L1GPR35HDAC1TBXAS1KDM4E
SCHEMBL13709557 0.84 C1S (0.50) BCL2L1GPR35HDAC1KDM4ESMN1; SMN2
SCHEMBL1886911 0.84 HDAC1 (0.78) BCL2L1GPR35HDAC1KDM4ESMN1; SMN2
Beta-Naphtoic Acid SCHEMBL27589159 0.83 BCL2L1 (0.75) BCL2L1GPR35HDAC1KDM4ESMN1; SMN2
SCHEMBL15697571 0.81 GPR35 (0.61) BCL2L1GPR35HDAC1TBXAS1HSD17B1
SCHEMBL191958 0.80 HDAC1 (0.51) HDAC1KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL156320 0.79 BCL2L1 (0.59) BCL2L1GPR35HDAC1TBXAS1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527698-B Europium (III) metal organic framework Eu-MOF probe material and preparation method and application thereof 西安石油大学 2022-07-19 CN claimed
CN-113527698-B Europium (III) metal organic framework Eu-MOF probe material and preparation method and application thereof 西安石油大学 2022-07-19 CN disclosed
CN-113527698-A Europium (III) metal organic framework Eu-MOF probe material and preparation method and application thereof 西安石油大学 2021-10-22 CN disclosed
US-9955689-B2 Method for promoting plant growth SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-01 US disclosed
US-9955689-B2 Method for promoting plant growth SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-01 US disclosed
US-9955689-B2 Method for promoting plant growth SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-01 US disclosed
US-20150289506-A1 METHOD FOR PROMOTING PLANT GROWTH SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-10-15 US disclosed
US-20150289506-A1 METHOD FOR PROMOTING PLANT GROWTH SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-10-15 US disclosed
US-20150289506-A1 METHOD FOR PROMOTING PLANT GROWTH SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-10-15 US disclosed
EP-2926660-A1 METHOD FOR PROMOTING PLANT GROWTH Sumitomo Chemical Company Limited (JP) 2015-10-07 EP disclosed
EP-2926660-A1 METHOD FOR PROMOTING PLANT GROWTH Sumitomo Chemical Company Limited (JP) 2015-10-07 EP disclosed
WO-2014073623-A1 METHOD FOR PROMOTING PLANT GROWTH 住友化学株式会社 (JP) 2014-05-15 WO disclosed
WO-2006117548-A1 HYDROXAMIC ACID DERVICATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY CHROMA THERAPEUTICS LTD (GB) 2006-11-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150289506-A1 METHOD FOR PROMOTING PLANT GROWTH FGF2, BROX, BOLA2; BOLA2B BCL2L1 2137/4885GPR35 3997/4885HDAC1 706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.