Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329508 | 0.79 | ALDH1A1 (0.41) | HSD17B10GAATSHRALDH1A1MAPT | |
| SCHEMBL8258042 | 0.73 | HTR3E (0.48) | MAPTKDM4EDRD4 | |
| SCHEMBL8255009 | 0.71 | ALDH1A1 (0.47) | TSHRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL4318159 | 0.70 | ALDH1A1 (0.48) | GAAALDH1A1MAPTKMT2AHTT | |
| SCHEMBL4318732 | 0.68 | LSS (0.39) | GAAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8258746 | 0.67 | ALDH1A1 (0.43) | ALDH1A1MAPTKMT2AHTTSMN1; SMN2 | |
| SCHEMBL5388551 | 0.67 | PARP1 (0.43) | DRD4 | |
| SCHEMBL8258604 | 0.65 | MEN1 (0.54) | GAATSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL4330719 | 0.64 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1DRD4 | |
| SCHEMBL5327466 | 0.63 | PKM (0.59) | GAATSHRALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |