Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 10/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017978 | 0.73 | KMT2A (0.51) | HIF1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16137403 | 0.64 | NPC1 (0.60) | NPC1POLBRAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL23085138 | 0.63 | CCNA2 (0.33) | MAPK14HIF1ASMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL5174953 | 0.62 | KCNN1 (0.61) | NPC1POLBRAB9A | |
| SCHEMBL19882763 | 0.57 | CES2 (0.42) | NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL24976005 | 0.57 | SIGMAR1 (0.34) | — | |
| SCHEMBL995168 | 0.57 | ALDH1A1 (0.38) | HIF1ANPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL15993666 | 0.56 | KDR (0.44) | HIF1ANPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL323086 | 0.56 | KDM4E (0.68) | HIF1ANPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL9393912 | 0.55 | KDM4E (0.48) | HIF1ANPC1POLBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |